The Physical Foundation of Protein Architecture

The Physical Foundation of Protein Architecture

eBook - 2001
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A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. The Physical Foundation of Protein Architecture is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed.
Publisher: Singapore ; River Edge, N.J. : World Scientific, Ă2001
ISBN: 9781281956576
1281956570
9789812811011
981281101X
9810247109
9789810247102
Characteristics: 1 online resource (ix, 144 pages) : illustrations
Additional Contributors: Kobayashi, Yukio

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